Photo credit
Marie Craig
Fellow
Padrón Raúl Alejandro
Full Professor
Current nationality
Venezuela (Bolivarian Republic of)
Current country of residence
United States of America (the)
Affiliation / Institution
Professor, Department of Radiology, Division of Cell Biology and Imaging, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A.
Biodata
Padrón work started at Cambridge´s MRC Laboratory of Molecular Biology. Padrón founded I.V.I.C.´s Center of Structural Biology, where he was an International Research Scholar of Howard Hughes Medical Institute. His group found by cryo-electron microscopy that in thick filaments of tarantula muscle the two heads form the myosin interacting-heads motif (IHM), where both ATPases were inhibited explaining relaxation (Nature 436: 1195, 2005). Their showing that IHM is conserved since before the origin of animals revealed IHM importance as a relaxation ATPase inhibition and ATP energy-saving mechanism. They proposed a cooperative phosphorylation activation mechanism that explains potentiation and post-tetanic potentiation on tarantula contracting muscles. They found that hypertrophic cardiomyopathy mutations cluster on IHM intramolecular interactions accounting for hypercontractility, reduced relaxation, and increased energy consumption of this pathogenesis. Honors: 1991 Polar Prize, 2008 Science and Technology National Prize of Venezuela. Elected Member of the Latin-American Academy of Sciences in 2002 and International Member of the National Academy of Sciences of the U.S.A. in 2018.
Sustainable Development Goals
Keywords
Structural biology, Muscle, Thick filaments, Myosin 2, Myosin interacting-heads motif (IHM), Thick filament activation, Super-relaxation (SRX), Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy (DCM)
ELECTED
2004
Section
02. Biological Sciences
Country where living and working for the majority of the last 10 years
United States of America (the)
Public contact information
EMAIL
raul.padron@umassmed.edu
PHONE
15088561675
Website, social media accounts or additional info
https://www.umassmed.edu/padron-craig/
Twitter @raulpadron
ADDRESS
Radiology Department
Last updated on 13/08/2024